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THERAPEUTIC AND TOXIC CONCENTRATIONS.pdf

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1999;40:129144.Repetto MR, Repetto M. According to the UK's National Poisons Information Service Annual Report 2010/2011, poisoning is an extremely common cause of hospital admissions in the National Health Service, being numerically similar to admissions for myocardial infarction [3].In the case of intoxication or poisoning, the concentration of the ingested substance and/or metabolite better predicts the clinical severity of the case and the potential outcome when compared to the assumed amount and time of ingestion. Greenwood Village, CO, USA: Thomson Reuters (Healthcare) Inc. Greenwood Village, CO, USA: Thomson Reuters (Healthcare) Inc; 2006. About The American Journal of Psychiatry Advertisers Media & Journalists Authors & Reviewers Reprints & Permissions Copyright American Psychiatric Association. Inter-individual deviation is, however, high. The data presented in the table and corresponding annotations have been developed over the past 20 years and longer. Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.

doi: 10.2165/00003088-197601060-00003. In order to keep the overall context clear, we preferred not to go into further details.Data about comatose or even fatal plasma concentrations consciously orient on life threatening or lethal intoxications which occurred at low plasma concentrations so that actual and potential dangers in clinical cases are not being underestimated. [PubMed]Baselt RC. Clin Pharmacokinet. Some suggestions: Go back to the last page Go to the home page . Yet even with this data, substantial deviation can be expected. 2. Authors' contributionsMS had the original idea, critically analysed the available data, reviewed other compilations and textbooks, searched and retrieved the original papers and drafted the manuscript. However, sufficient pharmacokinetic data are often not available. 1998;34:457482.

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